Investigating cancer risk in women with primary ovarian insufficiency
Comorbid Disease in Women with Primary Ovarian Insufficiency
This study is looking at how certain genes might be linked to primary ovarian insufficiency (POI) and a higher risk of cancer in women, and it invites women with POI to share their genetic information and family history to help find these connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11046944 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors associated with primary ovarian insufficiency (POI) and its link to increased cancer risk in women. By analyzing genetic data from women with POI and their families, the study aims to identify specific gene mutations that may contribute to both infertility and cancer susceptibility. The research employs advanced techniques such as whole exome sequencing and artificial intelligence algorithms to track cancer risk and genetic mutations. Patients may be involved in providing genetic samples and family history information to help uncover these important connections.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with primary ovarian insufficiency, particularly those with a family history of cancer.
Not a fit: Patients who do not have primary ovarian insufficiency or a relevant family history of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and preventive strategies for women with primary ovarian insufficiency regarding their cancer risk.
How similar studies have performed: Previous research has shown promising results in understanding genetic links between infertility and cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Welt, Corrine K — University of Utah
- Study coordinator: Welt, Corrine K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.