Investigating Canagliflozin's effects on brain health and aging
Canagliflozin as a Neuroprotective Agent to Improve Neuroinflammation and Cognitive Function during Aging
This study is looking at how Canagliflozin, a diabetes medication, might help keep older adults' brains healthy and improve thinking skills by reducing inflammation, which could be helpful in preventing issues like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10740151 on NIH RePORTER |
What this research studies
This research explores how Canagliflozin, a medication typically used for diabetes, may protect the brain and improve cognitive function in older adults. The study focuses on understanding how this drug can reduce neuroinflammation and enhance brain health as people age. By examining its effects in animal models, researchers aim to uncover the potential benefits of Canagliflozin for preventing or alleviating conditions like Alzheimer's disease. If successful, this research could lead to new treatment options for age-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those at risk for or experiencing cognitive decline or Alzheimer's disease.
Not a fit: Patients who are not elderly or do not have cognitive impairments related to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies to improve cognitive function and reduce neuroinflammation in older adults.
How similar studies have performed: Previous research has shown promising results with similar approaches in animal models, suggesting potential for success in human applications.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Sadagurski, Marianna — Wayne State University
- Study coordinator: Sadagurski, Marianna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.