Investigating CALHM channels in the nervous system
Structural and functional studies of CALHM channels
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11220169
This study is looking at how certain channels in our nervous system help with important functions like taste and hearing, and how problems with these channels might be linked to conditions like Alzheimer's and depression, with the hope of finding new ways to help treat these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11220169 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of CALHM channels in purinergic signaling within the nervous system, which is crucial for various functions such as taste, hearing, and neuroprotection. The study will explore how these channels facilitate the release of ATP and calcium, and how their dysregulation may contribute to neurological disorders like Alzheimer's disease and depression. By conducting structural and functional studies, the research aims to identify potential pharmacological targets for treatment. Patients may benefit from insights gained about CALHM channels and their implications for neurological health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological disorders such as Alzheimer's disease, depression, or those experiencing taste and hearing impairments.
Not a fit: Patients without neurological conditions or those not affected by taste or hearing issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders associated with CALHM channel dysfunction.
How similar studies have performed: While the specific focus on CALHM channels is relatively novel, there is existing research on purinergic signaling that has shown promise in understanding neurological functions and disorders.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LU, WEI — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: LU, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.