Investigating calcium transfer between cell organelles in pancreatic cancer
Endoplasmic Reticulum-to-Mitochondria Calcium Transfer in Pancreatic Cancer Development, Metastasis, and Treatment
This study is looking at how calcium movement between certain parts of cells might influence the growth and spread of pancreatic cancer, with the hope of finding new ways to treat this tough-to-treat disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10923821 on NIH RePORTER |
What this research studies
This research focuses on understanding how calcium transfer between the endoplasmic reticulum and mitochondria affects the development and spread of pancreatic cancer. By using advanced animal and cell-culture models, the researchers aim to explore the role of specific calcium channels in cancer cell survival and metastasis. The study seeks to identify new therapeutic targets that could lead to more effective treatments for pancreatic cancer, which is often diagnosed at an advanced stage and has poor treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic adenocarcinoma, particularly those with advanced disease.
Not a fit: Patients with early-stage pancreatic cancer or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that significantly improve outcomes for patients with pancreatic cancer.
How similar studies have performed: While the specific approach of targeting calcium transfer in pancreatic cancer is novel, similar strategies in other cancers have shown promising results.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Foskett, James Kevin — University of Pennsylvania
- Study coordinator: Foskett, James Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.