Investigating calcium signaling in the heart's atrial tissue
IP3 receptor, NOX2 and calcium signaling domains in atrial physiology and pathophysiology
This study is looking at how calcium signals in the heart can affect its ability to work properly, especially for people with heart failure or atrial fibrillation, to find new ways to help improve heart health and reduce irregular heartbeats.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11063110 on NIH RePORTER |
What this research studies
This research focuses on understanding how calcium signaling in the atrial tissue of the heart contributes to its function and dysfunction, particularly in conditions like heart failure and atrial fibrillation. The study examines the role of specific calcium release channels and their interactions with reactive oxygen species in regulating heart muscle contractions and electrical activity. By exploring these mechanisms, the research aims to identify potential targets for new treatments that could improve heart health and reduce arrhythmias.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with atrial fibrillation or heart failure who are experiencing issues related to heart rhythm and function.
Not a fit: Patients with non-cardiac conditions or those without any history of atrial fibrillation or heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce the risk of arrhythmias in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in cardiac tissues, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Banach, Kathrin — Rush University Medical Center
- Study coordinator: Banach, Kathrin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.