Investigating calcium crystal deposits in knee osteoarthritis
Project 3: Intraarticular Mineralization
This study is looking at how calcium crystals in the knee might be causing pain and swelling for people with osteoarthritis, and it hopes to find out if treating these crystals can help make you feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11056753 on NIH RePORTER |
What this research studies
This research focuses on understanding how calcium crystal deposits in the knee joint contribute to inflammation and pain in osteoarthritis (OA). By using advanced imaging techniques like dual energy CT, the study aims to identify the specific types of crystals present and their effects on OA symptoms. The researchers will analyze data from the Multicenter Osteoarthritis Study, including blood samples and synovial fluid, to explore the relationship between these deposits and inflammation. The goal is to determine if targeting these crystals with anti-inflammatory therapies could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with knee osteoarthritis who experience pain and inflammation.
Not a fit: Patients with knee osteoarthritis who do not have calcium crystal deposits or those with other unrelated joint conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that alleviate pain and improve function for patients with knee osteoarthritis.
How similar studies have performed: Previous research has shown that targeting inflammation in osteoarthritis can lead to meaningful improvements, suggesting potential success for this novel approach.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Neogi, Tuhina — Boston University Medical Campus
- Study coordinator: Neogi, Tuhina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.