Investigating calcium crystal deposits in knee osteoarthritis
Official title: Project 3: Intraarticular Mineralization
Funded at Boston University Medical Campus · NIH-11056753 · Data updated 2026-11-12
This study is looking at how calcium crystals in the knee might be causing pain and swelling for people with osteoarthritis, and it hopes to find out if treating these crystals can help make you feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,157,872 |
| NIH project number | 5U19AG076471-03 |
| Project ID | NIH-11056753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with knee osteoarthritis who experience pain and inflammation.
✕Less likely to help
Patients with knee osteoarthritis who do not have calcium crystal deposits or those with other unrelated joint conditions may not benefit from this research.
What this research studies
This research focuses on understanding how calcium crystal deposits in the knee joint contribute to inflammation and pain in osteoarthritis (OA). By using advanced imaging techniques like dual energy CT, the study aims to identify the specific types of crystals present and their effects on OA symptoms. The researchers will analyze data from the Multicenter Osteoarthritis Study, including blood samples and synovial fluid, to explore the relationship between these deposits and inflammation. The goal is to determine if targeting these crystals with anti-inflammatory therapies could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that alleviate pain and improve function for patients with knee osteoarthritis.
How similar studies have gone: Previous research has shown that targeting inflammation in osteoarthritis can lead to meaningful improvements, suggesting potential success for this novel approach.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Neogi, Tuhina — Boston University Medical Campus
- Study coordinator: Neogi, Tuhina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.