Investigating calcium channels in brain injury treatment
Calcium release-activated calcium (CRAC) channels in experimental traumatic brain injury
['FUNDING_OTHER'] · VETERANS AFFAIRS MED CTR SAN FRANCISCO · NIH-10951509
This study is looking at how blocking certain channels in brain cells might help improve recovery after a traumatic brain injury by calming down the brain's immune response, and it's aimed at finding safer treatment options for people who have experienced this kind of injury.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS AFFAIRS MED CTR SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10951509 on ClinicalTrials.gov |
What this research studies
This research focuses on calcium-release-activated calcium (CRAC) channels as a potential target for treating traumatic brain injury (TBI). It aims to understand how inhibiting the activation of microglia, the brain's immune cells, can improve neurological outcomes after TBI. The study will utilize laboratory models to explore the effects of CRAC channel inhibitors, which have shown promise in other inflammatory conditions. By targeting these channels, the research seeks to develop safer therapeutic options with fewer side effects compared to existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced traumatic brain injuries, particularly those with acute symptoms.
Not a fit: Patients with chronic brain injuries or those not experiencing acute symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and outcomes for patients with traumatic brain injuries.
How similar studies have performed: Previous research has shown success with CRAC channel inhibitors in other inflammatory conditions, suggesting potential for similar outcomes in TBI treatment.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- VETERANS AFFAIRS MED CTR SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YENARI, MIDORI A — VETERANS AFFAIRS MED CTR SAN FRANCISCO
- Study coordinator: YENARI, MIDORI A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, acute phase of SARS-CoV-2 infection, acute SARS-CoV-2 infection