Investigating calcium channels in brain injury treatment
Official title: Calcium release-activated calcium (CRAC) channels in experimental traumatic brain injury
Funded at Veterans Affairs Med Ctr San Francisco · NIH-10951509 · Data updated 2026-11-12
This study is looking at how blocking certain channels in brain cells might help improve recovery after a traumatic brain injury by calming down the brain's immune response, and it's aimed at finding safer treatment options for people who have experienced this kind of injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX004686-02 |
| Project ID | NIH-10951509 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced traumatic brain injuries, particularly those with acute symptoms.
✕Less likely to help
Patients with chronic brain injuries or those not experiencing acute symptoms may not benefit from this research.
What this research studies
This research focuses on calcium-release-activated calcium (CRAC) channels as a potential target for treating traumatic brain injury (TBI). It aims to understand how inhibiting the activation of microglia, the brain's immune cells, can improve neurological outcomes after TBI. The study will utilize laboratory models to explore the effects of CRAC channel inhibitors, which have shown promise in other inflammatory conditions. By targeting these channels, the research seeks to develop safer therapeutic options with fewer side effects compared to existing treatments.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and outcomes for patients with traumatic brain injuries.
How similar studies have gone: Previous research has shown success with CRAC channel inhibitors in other inflammatory conditions, suggesting potential for similar outcomes in TBI treatment.
Where this research is happening
-
Veterans Affairs Med Ctr San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Yenari, Midori a — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Yenari, Midori a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.