Investigating breath compounds and biomarkers to understand postoperative delirium in older adults
Exhaled volatile organic compounds, phospho-tau and postoperative delirium
This study is looking at how we can better predict confusion after surgery in older adults, especially those with Alzheimer's or similar conditions, by checking their breath and blood samples, and it’s designed for patients aged 65 and older who are having spine surgery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10732133 on NIH RePORTER |
What this research studies
This research focuses on understanding postoperative delirium (POD) in elderly patients, particularly those with Alzheimer's disease or related dementias. It aims to identify unique patterns of volatile organic compounds (VOCs) in the breath of patients who experience POD compared to those who do not. By analyzing these breath samples alongside blood biomarkers like phospho-tau, the study seeks to develop a non-invasive method for predicting POD, which can be performed at the bedside. The research will involve 150 patients aged 65 and older undergoing spine surgery, with the goal of improving early detection and management of POD.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly patients aged 65 and older who are scheduled for spine surgery.
Not a fit: Patients who are younger than 65 or those not undergoing spine surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a non-invasive method for early detection of postoperative delirium, improving outcomes for elderly patients.
How similar studies have performed: Previous research has shown promise in using breath analysis for various medical conditions, suggesting potential for success in this novel approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Finan, Patrick — University of Virginia
- Study coordinator: Finan, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.