Investigating brainstem microRNA changes related to sudden infant death syndrome.
Official title: Brainstem microRNA dysregulation in the pathogenesis of sudden infant death syndrome (SIDS)
Funded at Boston Children's Hospital · NIH-10951716 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in the brainstem might play a role in sudden infant death syndrome (SIDS), with the hope of finding new ways to help prevent it and keep babies safe.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 16, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $267,000 |
| NIH project number | 1R21HD116005-01 |
| Project ID | NIH-10951716 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants who are at risk for SIDS or have experienced unexplained infant deaths.
✕Less likely to help
Patients who are older children or adults, or those without a history of SIDS risk factors, may not benefit from this research.
What this research studies
This research focuses on understanding the biological factors in the brainstem that may contribute to sudden infant death syndrome (SIDS). It examines specific microRNAs that are altered in infants who have died from SIDS, particularly looking at their role in serotonin function and inflammation. By analyzing these microRNAs and their target proteins, the research aims to uncover potential mechanisms that make infants vulnerable to SIDS. This could lead to new insights into prevention strategies and therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for sudden infant death syndrome.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in various neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
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Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Haynes, Robin Lynn — Boston Children's Hospital
- Study coordinator: Haynes, Robin Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.