Investigating brainstem dysfunction and inflammation in sudden infant death syndrome (SIDS)
Official title: Inflammatory stressors in serotonergic brainstem dysfunction and SIDS
Funded at Boston Children's Hospital · NIH-11058431 · Data updated 2026-11-12
This study is looking into how certain brain issues might make babies more vulnerable to sudden infant death syndrome (SIDS) and how things like low oxygen or infections could make it worse, with the hope of finding ways to reduce the risk of SIDS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $723,152 |
| NIH project number | 5R01HD107060-03 |
| Project ID | NIH-11058431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants at risk for SIDS, particularly those with a family history or exposure to known risk factors.
✕Less likely to help
Patients who are older children or adults, or those without any risk factors for SIDS, may not benefit from this research.
What this research studies
This research focuses on understanding the biological vulnerabilities associated with sudden infant death syndrome (SIDS) by examining serotonergic dysfunction in the brainstem. It aims to identify how external stressors, such as hypoxia and infections, may exacerbate these vulnerabilities and lead to SIDS. By analyzing tissue samples and using animal models, the study seeks to uncover potential biomarkers and preventative strategies that could help reduce the risk of SIDS. The findings may provide insights into the neuroinflammatory processes that contribute to this condition.
Why it matters
Potential benefit: If successful, this research could lead to new preventative measures and interventions that significantly reduce the incidence of SIDS.
How similar studies have gone: Previous research has shown promising results in understanding the role of neuroinflammation and serotonergic dysfunction in SIDS, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Haynes, Robin Lynn — Boston Children's Hospital
- Study coordinator: Haynes, Robin Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.