Investigating brainstem dysfunction and inflammation in sudden infant death syndrome (SIDS)
Inflammatory stressors in serotonergic brainstem dysfunction and SIDS
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11058431
This study is looking into how certain brain issues might make babies more vulnerable to sudden infant death syndrome (SIDS) and how things like low oxygen or infections could make it worse, with the hope of finding ways to reduce the risk of SIDS.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11058431 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the biological vulnerabilities associated with sudden infant death syndrome (SIDS) by examining serotonergic dysfunction in the brainstem. It aims to identify how external stressors, such as hypoxia and infections, may exacerbate these vulnerabilities and lead to SIDS. By analyzing tissue samples and using animal models, the study seeks to uncover potential biomarkers and preventative strategies that could help reduce the risk of SIDS. The findings may provide insights into the neuroinflammatory processes that contribute to this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants at risk for SIDS, particularly those with a family history or exposure to known risk factors.
Not a fit: Patients who are older children or adults, or those without any risk factors for SIDS, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventative measures and interventions that significantly reduce the incidence of SIDS.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuroinflammation and serotonergic dysfunction in SIDS, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAYNES, ROBIN LYNN — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: HAYNES, ROBIN LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.