Investigating brain wave patterns in Alzheimer's disease
Official title: High frequency oscillations in Alzheimer's disease
Funded at Nathan S. Kline Institute for Psych Res · NIH-11058153 · Data updated 2026-11-12
This study is looking at unusual brain wave patterns in Alzheimer's disease to see if they can help us understand memory problems better and find new ways to improve memory, using special technology to track these patterns in mice.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $454,024 |
| NIH project number | 1R21AG086880-01A1 |
| Project ID | NIH-11058153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals at risk for Alzheimer's disease or those in the early stages of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding abnormal brain wave patterns, specifically high frequency oscillations (HFOs), in Alzheimer's disease. By using advanced EEG technology, the study aims to identify these oscillations as potential biomarkers for the disease and explore their role in memory impairment. The research will involve monitoring these brain wave patterns in mouse models to see how they change over time and how they might be manipulated to improve memory function. This approach could lead to new insights into the progression of Alzheimer's and potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new non-invasive biomarkers for early detection of Alzheimer's disease and innovative methods to enhance memory function.
How similar studies have gone: While the investigation of high frequency oscillations in Alzheimer's is a relatively novel approach, similar studies in epilepsy have shown promising results.
Where this research is happening
-
Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Lisgaras, Christos Panagiotis — Nathan S. Kline Institute for Psych Res
- Study coordinator: Lisgaras, Christos Panagiotis
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.