Investigating brain tissue quality and multi-omic data for Alzheimer's disease
Official title: Validation of penta-omic assays in brain tissue and identification of markers of tissue and -omic data quality
Funded at Univ of North Carolina Chapel Hill · NIH-10952185 · Data updated 2026-11-12
This study is looking at ways to better understand Alzheimer's disease by using a special technique to gather different types of biological information from one brain tissue sample, which could help researchers find better ways to diagnose and treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $440,079 |
| NIH project number | 1R21AG088936-01 |
| Project ID | NIH-10952185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those whose brain tissue may be available for study post-mortem.
✕Less likely to help
Patients who are not diagnosed with Alzheimer's disease or related dementias, or those who do not have post-mortem brain tissue available, may not benefit from this research.
What this research studies
This research focuses on improving the understanding of Alzheimer's disease and related dementias by developing a new method to extract multiple types of biological data (penta-omic data) from a single brain tissue sample. By utilizing a unique extraction technique called SiMPL-DREx, the study aims to minimize variability that arises from using multiple samples, thereby creating a more reliable database of brain tissue characteristics. This approach will help researchers better analyze the quality of various biological markers associated with Alzheimer's disease, potentially leading to improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to more accurate assessments of brain tissue quality and enhance the understanding of Alzheimer's disease, ultimately improving patient care and treatment options.
How similar studies have gone: While multi-omic approaches are gaining traction, this specific penta-omic method is novel and has not been extensively tested in previous studies.
Where this research is happening
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Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Macdonald, Jeffrey M. — Univ of North Carolina Chapel Hill
- Study coordinator: Macdonald, Jeffrey M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.