Investigating brain tissue metabolites in diverse populations with Alzheimer's disease
Characterizing the AD Metabolome in Brain Tissue Samples of Individuals from Diverse Populations
This study is looking at brain tissue from people with Alzheimer's disease from different backgrounds to find out how their unique genetics and environments might affect the disease, which could help create better treatments for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10659891 on NIH RePORTER |
What this research studies
This research focuses on understanding the metabolome, or the complete set of metabolites, in brain tissue samples from individuals with Alzheimer's disease (AD) from various racial and ethnic backgrounds. By including diverse populations, the study aims to identify unique metabolic pathways and genetic factors that may influence the risk and progression of AD. The approach involves analyzing brain tissue samples to uncover how environmental and genetic factors interact in different populations, particularly in relation to cardiovascular health, which is believed to affect AD prevalence. This comprehensive analysis could lead to better patient stratification for clinical trials and more effective therapies tailored to diverse groups.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse racial and ethnic backgrounds who are diagnosed with Alzheimer's disease.
Not a fit: Patients who are not diagnosed with Alzheimer's disease or who do not belong to diverse racial or ethnic groups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of Alzheimer's disease in diverse populations, ultimately enhancing patient outcomes.
How similar studies have performed: While there have been successful metabolomics studies in Caucasian populations, this research is novel as it aims to include diverse populations, which has not been extensively explored.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — Duke University
- Study coordinator: Kaddurah-Daouk, Rima F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.