Investigating brain tissue changes in Alzheimer's disease using advanced MRI techniques
Revealing tissue microstructure in the brain gray matter in Alzheimer's disease using in vivo high-gradient diffusion MRI
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10918097
This study is looking at a special type of brain scan to see tiny changes in the brain of people with Alzheimer's disease, which could help catch problems early and improve treatment options.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10918097 on ClinicalTrials.gov |
What this research studies
This research focuses on using high-gradient diffusion MRI to explore the microstructure of brain gray matter in individuals with Alzheimer's disease. By employing this advanced imaging technique, the study aims to identify early pathological changes that occur in the brain before significant cognitive decline. This non-invasive approach allows for the monitoring of disease progression and response to therapies, potentially leading to earlier interventions. The research will specifically analyze changes in brain tissue that are often overlooked by traditional imaging methods.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or mild cognitive impairment.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better monitoring of Alzheimer's disease, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in using diffusion MRI for studying brain changes in Alzheimer's, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, HONG HSI — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: LEE, HONG HSI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome