Investigating brain structure changes in aging and Alzheimer's disease
Official title: Relationships between sulcal morphology, neuropathology, and cognition in aging and Alzheimer's disease
Funded at University of California Berkeley · NIH-10826397 · Data updated 2026-11-12
This study is looking at how changes in certain parts of the brain might be linked to memory and thinking problems in older adults, including those with Alzheimer's disease, by comparing brain scans from healthy seniors and those with the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $45,483 |
| NIH project number | 1F31AG082446-01A1 |
| Project ID | NIH-10826397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include cognitively normal older adults and older adults diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with other forms of dementia or significant neurological disorders unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research explores how changes in the brain's surface structure, specifically the tertiary sulci, relate to cognitive decline and Alzheimer's disease (AD). By using advanced imaging techniques like PET and MRI, the study will analyze brain scans from cognitively healthy older adults and those with AD to understand how these structural changes correlate with cognitive function and the presence of amyloid plaques. The goal is to identify specific brain morphology patterns that could indicate the progression of cognitive impairment in aging and AD.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and early detection of cognitive decline in aging and Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding brain morphology and cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Maboudian, Samira Alessandra — University of California Berkeley
- Study coordinator: Maboudian, Samira Alessandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.