Investigating brain signals related to working memory in people with psychosis

Measurement and manipulation of oscillatory biomarker of working memory in psychosis

NIH-funded research University of Chicago · NIH-10808860

This study is looking at how working memory works in people with psychosis and whether training to change certain brain signals can help improve their memory skills.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Chicago NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-10808860 on NIH RePORTER

What this research studies

This research focuses on understanding how working memory is affected in individuals with psychosis by examining specific brain signals known as oscillatory biomarkers. The study aims to identify the neurobiological mechanisms behind working memory impairments and to explore the potential of neurofeedback training to improve memory retention. Participants will be trained to modulate their brain signals, specifically alpha desynchronization, to see if this can enhance their working memory capacity. The approach combines advanced brain imaging techniques with cognitive training methods.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with psychotic disorders who experience difficulties with working memory.

Not a fit: Patients without psychotic disorders or those who do not experience working memory impairments may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved cognitive interventions for individuals with psychosis, enhancing their working memory and overall cognitive function.

How similar studies have performed: Previous research has shown promising results in using neurofeedback to enhance cognitive functions, suggesting that this approach may be effective for individuals with psychosis as well.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.