Investigating brain signals related to attention and performance in tasks.
Official title: Validation of electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention
Funded at Lieber Institute, INC. · NIH-11136267 · Data updated 2026-11-12
This study is looking at how well people and animals can stay focused over time, especially if they have certain brain disorders, and it will test how different things, like medication, can help improve attention.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lieber Institute, INC. NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $647,730 |
| NIH project number | 5R01MH137057-02 |
| Project ID | NIH-11136267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing attentional deficits due to brain disorders.
✕Less likely to help
Patients without any attentional deficits or those not affected by brain disorders may not benefit from this research.
What this research studies
This research focuses on understanding how sustained attention, the ability to maintain focus over time, is affected in various brain disorders. By using continuous performance tests (CPTs), the study aims to measure attention levels in both humans and animal models. The researchers will optimize these tests to see how different factors, like the percentage of targets presented, influence attention and performance. Additionally, they will explore how amphetamines, known to enhance performance, affect brain activity related to attention. This work could lead to better treatments for attentional deficits.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for individuals with attention-related disorders, enhancing their quality of life.
How similar studies have gone: Previous research has shown promise in using similar electrophysiological approaches to understand attention and performance, indicating a potential for success in this area.
Where this research is happening
-
Lieber Institute, INC.
Baltimore, United States Active
Researchers
- Principal investigator: Carr, Gregory V — Lieber Institute, INC.
- Study coordinator: Carr, Gregory V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.