Investigating brain responses to anesthetics in older adults at risk for Alzheimer's disease
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
This study is looking at how brain activity changes when older adults are given anesthesia, to see if it can help spot early signs of Alzheimer's disease and identify those who might be at risk for confusion after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11080931 on NIH RePORTER |
What this research studies
This research focuses on understanding how changes in brain activity in response to anesthetics may indicate early signs of Alzheimer's disease in older adults. It examines the relationship between amyloid beta deposits in the brain and the risk of developing delirium after surgery. By analyzing brain responses during anesthesia, the study aims to identify markers that could help predict which patients are at higher risk for cognitive decline. This could lead to better preoperative assessments and tailored interventions for older surgical patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are scheduled for surgery and may have early signs of Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without any signs of cognitive decline or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help identify older adults at risk for Alzheimer's disease and improve their surgical outcomes by minimizing the risk of delirium.
How similar studies have performed: Previous research has shown that monitoring brain activity in response to anesthetics can provide insights into cognitive health, suggesting that this approach may yield valuable findings.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Devinney, Michael Joseph — Duke University
- Study coordinator: Devinney, Michael Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.