Investigating brain receptors to develop new medications for alcohol use disorder
NOP Receptors in nonhuman primate models of AUD
['FUNDING_R01'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-10828887
This study is exploring new ways to help people with alcohol use disorder by looking at how certain brain receptors can be targeted with new medications, using nonhuman primates to see if these treatments can reduce drinking.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-10828887 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific brain receptors, known as nociceptin/orphanin FQ peptide (NOP) receptors, can be targeted to create new treatments for alcohol use disorder (AUD). Using nonhuman primate models, the study will assess the effects of novel medications that interact with these receptors, alongside traditional drugs, to evaluate their effectiveness in reducing alcohol consumption. The research employs advanced techniques such as pharmacotherapy assessment and noninvasive brain imaging to gather comprehensive data on the impact of these treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are experiencing alcohol use disorder.
Not a fit: Patients who do not have alcohol use disorder or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective medications for individuals struggling with alcohol use disorder.
How similar studies have performed: Previous research has shown promising results in rodent models, but this approach in nonhuman primates is relatively novel and untested.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CZOTY, PAUL W. — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: CZOTY, PAUL W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.