Investigating brain receptors related to cognitive function in schizophrenia
PET Imaging of alpha 7 and alpha4beta2-nAChR in Schizophrenia: Cognitive Relationships
This study is looking at how certain brain receptors might affect thinking skills in people with schizophrenia, and it will involve brain scans and genetic testing to see how these factors work together, helping us understand more about the challenges faced by those with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10624751 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific brain receptors, known as α7-nAChR, in individuals with schizophrenia and how these receptors relate to cognitive deficits. Using a specialized imaging technique called positron emission tomography (PET), the study aims to measure the availability of these receptors in the brain of patients diagnosed with schizophrenia. By enrolling 60 patients with schizophrenia and 60 matched controls, the research will also explore genetic factors that may influence receptor availability and cognitive function. The findings could provide insights into the biological underpinnings of cognitive impairments associated with schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who are willing to participate in imaging studies and genetic testing.
Not a fit: Patients without a diagnosis of schizophrenia or those who do not meet the study's specific inclusion criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive deficits in patients with schizophrenia.
How similar studies have performed: Previous studies have shown promising results in using PET imaging to investigate brain receptor availability in various psychiatric conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Wong, Dean Foster — Washington University
- Study coordinator: Wong, Dean Foster
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.