Investigating brain pathology in neurodegenerative diseases using advanced imaging techniques
Clinical Core
This study is looking at new ways to take pictures of the brain to better understand and diagnose neurodegenerative diseases like Parkinson's and certain types of dementia, so if you or someone you know is dealing with these conditions, your participation could help improve future treatments and care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10940633 on NIH RePORTER |
What this research studies
This research focuses on using innovative PET imaging with new radiotracers to study brain pathology associated with neurodegenerative diseases such as Parkinson's disease, Multiple Systems Atrophy, Progressive Supranuclear Palsy, and frontotemporal dementias. By targeting specific proteins like α-synuclein and 4 repeat tau, the research aims to improve diagnostic accuracy and understanding of these conditions. Participants will undergo careful evaluations to ensure accurate diagnosis, which is crucial given the complexities of these disorders. The findings could lead to better treatment strategies and improved patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with Parkinson's disease, Multiple Systems Atrophy, Progressive Supranuclear Palsy, or frontotemporal dementias.
Not a fit: Patients with other forms of dementia or neurodegenerative disorders not related to α-synuclein or 4 repeat tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance diagnostic methods and lead to the development of more effective treatments for neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in using PET imaging for similar neurodegenerative conditions, indicating a potential for success in this novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Perlmutter, Joel Synes — University of Pennsylvania
- Study coordinator: Perlmutter, Joel Synes
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.