Investigating brain organoids to understand neurodevelopmental disorders
A Phenotypical Brain Organoids for Neurodevelopmental Disorders
This study is looking at tiny brain models made from patient cells to better understand neurodevelopmental disorders, helping us learn how these conditions affect brain growth and function, so we can improve care for those who have them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10973761 on NIH RePORTER |
What this research studies
This research focuses on using human brain organoids derived from patient cells to explore neurodevelopmental disorders (NDDs), which affect brain development and lead to lifelong impairments. By analyzing a library of 750 unique patient-derived organoid lines, the research aims to identify how these organoids can reflect the clinical characteristics of NDDs. The study will employ advanced techniques to uncover the cellular and molecular changes associated with disrupted brain development and investigate how genes and environmental factors interact in these conditions. This approach seeks to provide a more accurate model for understanding NDDs compared to traditional animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diagnosed neurodevelopmental disorders or those with a family history of such conditions.
Not a fit: Patients with neurodevelopmental disorders that are not represented in the specific patient-derived iPSC library may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for neurodevelopmental disorders in children.
How similar studies have performed: Previous research using human brain organoids has shown promise in modeling various neurological conditions, indicating a potential for success in this novel approach.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Wang, Lu — University of Southern California
- Study coordinator: Wang, Lu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.