Investigating brain networks involved in Alzheimer's disease
Network Medicine for Alzheimers Disease: Functional Dissection and Pharmacologic Perturbation of a Human Brain Synaptic Regulatory Expression Signature
This study is looking at how Alzheimer's disease affects brain connections by examining brain tissue samples, and it's for anyone interested in finding new ways to protect brain cells and improve treatments for Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10503884 on NIH RePORTER |
What this research studies
This research focuses on understanding the biological networks that are disrupted in Alzheimer's disease by analyzing brain tissue samples. By collaborating with the Accelerating Medicines Partnership, the team has identified specific molecular networks linked to the disease using RNA sequencing from thousands of human brain autopsy samples. The findings will be tested in experimental models to explore potential new therapies that target these networks, particularly focusing on a gene network related to synaptic regulation and excitatory signaling. This approach aims to uncover new treatment strategies that could help protect neurons from damage associated with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that better protect brain function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting similar biological networks in Alzheimer's, suggesting potential for success in this approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Shulman, Joshua M — Baylor College of Medicine
- Study coordinator: Shulman, Joshua M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.