Investigating brain network changes in neurodegenerative diseases linked to TDP-43
Understanding dynamics of brain network in TDP-43 related neurodegeneration
This study is looking at how a protein called TDP-43, which doesn't end up where it should in the brain, might play a role in diseases like Alzheimer's and ALS, and it's using special imaging techniques in mice to find new ways to understand how brain activity changes over time, which could help in finding new treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10980494 on NIH RePORTER |
What this research studies
This research focuses on understanding how the mislocalization of TDP-43 protein contributes to neurodegenerative diseases like Alzheimer's and ALS. By using advanced calcium imaging techniques in TDP-43 knockout mouse models, the study aims to develop new methods for analyzing the dynamic changes in brain networks over time. The researchers will create a Bayesian computational system to better model these changes, which could lead to insights into disease progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.
Not a fit: Patients with neurodegenerative diseases not related to TDP-43 mislocalization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with neurodegenerative diseases associated with TDP-43.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to study brain networks, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Chen, Rong — University of Maryland Baltimore
- Study coordinator: Chen, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.