Investigating brain mechanisms involved in sudden unexpected death in epilepsy
The role of brainstem projecting extended amygdala neurons in sudden unexpected death in epilepsy
This study is looking at how certain brain cells might be linked to sudden unexpected death in epilepsy (SUDEP) to help find ways to prevent it, especially for people who have uncontrolled seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10930106 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific neurons in the brain that may contribute to sudden unexpected death in epilepsy (SUDEP), a serious risk for patients with uncontrolled seizures. By studying the connections between the amygdala and brainstem, the researchers aim to uncover how seizure-related respiratory dysfunction can lead to life-threatening conditions like hypoventilation and cardiac issues. The project utilizes advanced techniques in a mouse model to identify the neural circuits involved, which could ultimately help in developing strategies to predict and prevent SUDEP.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with refractory epilepsy who are at risk for sudden unexpected death.
Not a fit: Patients with well-controlled epilepsy or those who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for predicting and preventing sudden unexpected death in epilepsy, significantly improving patient safety.
How similar studies have performed: While the specific approach of this research is novel, previous studies have indicated that understanding brain mechanisms related to seizures can lead to significant advancements in epilepsy treatment.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Nobis, William Paul — Vanderbilt University Medical Center
- Study coordinator: Nobis, William Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.