Investigating brain interactions related to memory loss in Alzheimer's disease models
Entorhinal-hippocampal interactions during progressive memory impairments in mouse models of Alzheimer's disease pathology
This study is looking at how certain parts of the brain work together and affect memory problems in Alzheimer's disease, using mice that have similar symptoms, to find new ways to help improve memory and prevent further decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11258121 on NIH RePORTER |
What this research studies
This research focuses on understanding how interactions between specific brain regions contribute to memory impairments in Alzheimer's disease. Using mouse models that mimic the disease, the study examines how changes in the medial entorhinal cortex affect hippocampal function and memory processing. By identifying early alterations in brain activity and connections, the research aims to uncover potential targets for new treatments that could help prevent or reverse cognitive decline. The approach combines advanced techniques in neuroscience to analyze brain circuits involved in memory.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with early-stage Alzheimer's disease or those at risk of developing the condition.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better address memory loss in Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in understanding brain interactions in Alzheimer's disease, but this specific approach is novel and aims to fill critical gaps in knowledge.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Shuman, Tristan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Shuman, Tristan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.