Investigating brain injury risks in newborns with congenital heart disease.
The Risk of Acquired Neonatal Significant brain Injury during perinatal Transition in Congenital Heart Disease: TRANSIT CHD study
This study is looking at how changes in blood flow and heart function when babies are born can impact brain health in newborns with a heart condition called transposition of the great arteries, and it aims to find ways to protect their brains and improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11044203 on NIH RePORTER |
What this research studies
This research focuses on understanding how changes in blood flow and heart function during the transition from fetal to neonatal life can affect brain health in newborns with congenital heart disease, specifically transposition of the great arteries (TGA). By using advanced imaging techniques, the study aims to identify biomarkers that could indicate the risk of brain injury in these infants. The research will explore potential neuroprotective interventions, such as delayed cord clamping, to improve outcomes for affected newborns. The goal is to provide insights that could lead to better management strategies for these vulnerable patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with congenital heart disease, particularly those with transposition of the great arteries.
Not a fit: Patients without congenital heart disease or those who are not newborns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing brain injuries in newborns with congenital heart disease.
How similar studies have performed: Previous research has shown promise in using neuroprotective strategies during the perinatal period, indicating potential for success in this approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Peyvandi, Shabnam — University of California, San Francisco
- Study coordinator: Peyvandi, Shabnam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.