Investigating brain injury risks in newborns with congenital heart disease.
Official title: The Risk of Acquired Neonatal Significant brain Injury during perinatal Transition in Congenital Heart Disease: TRANSIT CHD study
Funded at University of California, San Francisco · NIH-11044203 · Data updated 2026-11-12
This study is looking at how changes in blood flow and heart function when babies are born can impact brain health in newborns with a heart condition called transposition of the great arteries, and it aims to find ways to protect their brains and improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $506,164 |
| NIH project number | 5R01NS125404-04 |
| Project ID | NIH-11044203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with congenital heart disease, particularly those with transposition of the great arteries.
✕Less likely to help
Patients without congenital heart disease or those who are not newborns may not benefit from this research.
What this research studies
This research focuses on understanding how changes in blood flow and heart function during the transition from fetal to neonatal life can affect brain health in newborns with congenital heart disease, specifically transposition of the great arteries (TGA). By using advanced imaging techniques, the study aims to identify biomarkers that could indicate the risk of brain injury in these infants. The research will explore potential neuroprotective interventions, such as delayed cord clamping, to improve outcomes for affected newborns. The goal is to provide insights that could lead to better management strategies for these vulnerable patients.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing brain injuries in newborns with congenital heart disease.
How similar studies have gone: Previous research has shown promise in using neuroprotective strategies during the perinatal period, indicating potential for success in this approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Peyvandi, Shabnam — University of California, San Francisco
- Study coordinator: Peyvandi, Shabnam
Related research
Other NIH-funded projects on the same topics.
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Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains
This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.
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Newborn brain injury risk during birth transition in babies with congenital heart defects
This project will look at how circulation changes around birth affect newborn brain health in babies with transposition of the great arteries.
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Protecting newborn brains in babies born with transposition of the great arteries
Doctors will follow babies with transposition of the great arteries from pregnancy through birth to find early signs and ways to protect their brains during the newborn transition.
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Brain injury risks in preterm newborns with congenital heart disease
This grant studies how being born preterm with congenital heart disease affects brain development and injury, to help improve outcomes for affected babies.
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Investigating brain injury in preterm newborns with congenital heart disease
This study is looking at how different heart surgeries for newborns with congenital heart disease might affect their brain development and risk of injury, especially for those born early, and it also checks if genetics play a role in their outcomes, all to help these little ones have better futures.
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Multimodal AI to improve genetic diagnosis of congenital heart disease
A new AI tool uses multiple types of patient data to help doctors find genetic causes of congenital heart disease more accurately.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.