Investigating brain injury in preterm newborns with congenital heart disease
Official title: Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm
Funded at University of California, San Francisco · NIH-11053571 · Data updated 2026-11-12
This study is looking at how different heart surgeries for newborns with congenital heart disease might affect their brain development and risk of injury, especially for those born early, and it also checks if genetics play a role in their outcomes, all to help these little ones have better futures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $802,803 |
| NIH project number | 5R01HL165400-03 |
| Project ID | NIH-11053571 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns under 4 weeks old who are born preterm and diagnosed with congenital heart disease.
✕Less likely to help
Patients who are not newborns or those without congenital heart disease may not benefit from this research.
What this research studies
This research focuses on understanding the risks of brain injury and neurodevelopmental issues in newborns who are both preterm and have congenital heart disease (CHD). By examining different surgical strategies used to treat heart defects, the study aims to determine how these interventions impact brain development and injury risk. The research will also include genetic evaluations to see how genetic factors may influence outcomes. This comprehensive approach aims to improve the long-term neurodevelopmental outcomes for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance brain development and reduce injury in newborns with congenital heart disease.
How similar studies have gone: Previous research has shown promising results in understanding brain injury in newborns with congenital conditions, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Mcquillen, Patrick Sean — University of California, San Francisco
- Study coordinator: Mcquillen, Patrick Sean
Related research
Other NIH-funded projects on the same topics.
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Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains
This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.
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Brain injury risks in preterm newborns with congenital heart disease
This grant studies how being born preterm with congenital heart disease affects brain development and injury, to help improve outcomes for affected babies.
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Newborn brain injury risk during birth transition in babies with congenital heart defects
This project will look at how circulation changes around birth affect newborn brain health in babies with transposition of the great arteries.
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Protecting newborn brains in babies born with transposition of the great arteries
Doctors will follow babies with transposition of the great arteries from pregnancy through birth to find early signs and ways to protect their brains during the newborn transition.
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Investigating brain injury risks in newborns with congenital heart disease.
This study is looking at how changes in blood flow and heart function when babies are born can impact brain health in newborns with a heart condition called transposition of the great arteries, and it aims to find ways to protect their brains and improve their care.
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Multimodal AI to improve genetic diagnosis of congenital heart disease
A new AI tool uses multiple types of patient data to help doctors find genetic causes of congenital heart disease more accurately.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.