Investigating brain injury and epilepsy mechanisms using advanced imaging techniques
Official title: Multiphoton In Vivo Microscopy (Core 2)
Funded at Massachusetts General Hospital · NIH-11088159 · Data updated 2026-11-12
This study is looking at how brain injuries can lead to epilepsy, using special imaging tools to see what's happening in the brain over time, and the goal is to find better treatments for people who develop epilepsy after a head injury.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $47,243 |
| NIH project number | 5P01NS127769-03 |
| Project ID | NIH-11088159 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced traumatic brain injuries and are at risk of developing epilepsy.
✕Less likely to help
Patients with epilepsy not related to traumatic brain injury may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the cellular and molecular processes that lead to epilepsy following traumatic brain injury. By utilizing advanced fluorescence microscopy, the team aims to collect detailed data from large animal models, allowing for high-resolution imaging of brain structures over time. The project involves developing specialized imaging tools that can capture intricate details of brain activity and chemical changes, which are crucial for identifying the underlying mechanisms of post-traumatic epilepsy. Patients may benefit from insights gained through this research that could lead to improved treatments for epilepsy resulting from brain injuries.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating epilepsy in patients who have suffered traumatic brain injuries.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study brain injuries and their effects, indicating that this approach may yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Lillis, Kyle Patrick — Massachusetts General Hospital
- Study coordinator: Lillis, Kyle Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.