Investigating brain immune cells and their role in Alzheimer's disease
Microglia-specific proteomic mechanisms and biomarkers of neuroinflammation in Alzheimer’s disease
This study is looking at how brain immune cells called microglia might play a role in inflammation related to Alzheimer's disease, using a special technique to track changes in proteins they produce, which could help find new ways to treat or diagnose the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11078814 on NIH RePORTER |
What this research studies
This research focuses on understanding how microglia, the immune cells in the brain, contribute to neuroinflammation in Alzheimer's disease (AD). By using a novel technique called ciBONCAT, researchers aim to label and analyze proteins produced by microglia in living organisms, which will help identify molecular changes associated with AD. This approach allows for a more accurate understanding of the disease mechanisms at the protein level, rather than relying solely on genetic information. The findings could lead to new therapeutic strategies and biomarkers for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
Not a fit: Patients with other forms of dementia or neurodegenerative diseases unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments and diagnostic tools for Alzheimer's disease.
How similar studies have performed: Previous research using proteomic approaches in neurodegenerative diseases has shown promise, suggesting that this novel method could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Rangaraju, Srikant — Yale University
- Study coordinator: Rangaraju, Srikant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.