Investigating brain imaging to understand cognitive decline in multiple sclerosis
Official title: Multi-scale, multi-modal imaging assessment of trajectories of cognitive impairment in Multiple Sclerosis
Funded at Weill Medical Coll of Cornell Univ · NIH-10981498 · Data updated 2026-11-12
This study is looking at how multiple sclerosis affects thinking and memory by using special brain scans, and it's aimed at finding ways to create personalized treatments that can help keep your mind sharp.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 8, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $694,369 |
| NIH project number | 1R01NS134646-01A1 |
| Project ID | NIH-10981498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing cognitive impairment.
✕Less likely to help
Patients with cognitive impairment due to conditions other than multiple sclerosis may not benefit from this research.
What this research studies
This research focuses on understanding cognitive impairment in patients with multiple sclerosis (MS) by using advanced brain imaging techniques. It employs diffusion MRI and functional MRI to analyze changes in brain structure and connectivity over time. By examining both macroscopic and microscopic brain changes, the study aims to identify specific brain networks associated with cognitive decline. The ultimate goal is to develop personalized therapies that can help preserve cognitive function in MS patients.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies that improve cognitive function in patients with multiple sclerosis.
How similar studies have gone: Previous research using similar imaging techniques has shown promise in understanding cognitive impairment in neurological conditions, suggesting potential for success in this approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Gauthier, Susan a — Weill Medical Coll of Cornell Univ
- Study coordinator: Gauthier, Susan a
Related research
Other NIH-funded projects on the same topics.
-
Multi-Scale Brain Imaging to Track Cognitive Change in Multiple Sclerosis
A brain-imaging study in people with multiple sclerosis aims to map how brain connections relate to getting worse or staying the same in thinking skills.
-
Understanding Cognitive Changes in Multiple Sclerosis Using Advanced Brain Imaging
This research aims to better understand why some people with multiple sclerosis experience memory and thinking problems by looking closely at their brain changes over time.
-
Susceptibility-based MRI biomarkers for multiple sclerosis
A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.
-
Improving Neurological Health with Brain Training for Mild Cognitive Impairment (INHANCE-MCI)
A computer-based brain training program is being tested to help people with mild cognitive impairment maintain thinking skills and daily functioning.
-
Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
-
Blood stem cell changes linked to mild memory problems and worsening kidney function
This project will see if age-related changes in blood stem cells (clonal hematopoiesis) are tied to mild thinking problems and faster kidney decline in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.