Investigating brain imaging markers in early Alzheimer's disease and cognitive decline
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline
This study is looking at a tiny part of the brain called the locus coeruleus to see how it changes in older adults, helping us understand the differences between those who age well and those who may develop Alzheimer's or other memory issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11088865 on NIH RePORTER |
What this research studies
This research focuses on examining brain imaging markers in a small brainstem area known as the locus coeruleus, which plays a crucial role in cognitive function. The study aims to compare these markers in older adults who age healthily versus those who develop Alzheimer's disease or cognitive decline. By tracking changes in these imaging markers over time, the research seeks to enhance our understanding of how early brain changes can indicate the progression of Alzheimer's and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are at risk for Alzheimer's disease or cognitive decline, particularly those with early signs of cognitive changes.
Not a fit: Patients who are not experiencing any cognitive decline or do not have risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and monitoring of Alzheimer's disease and cognitive decline.
How similar studies have performed: Previous research has shown promise in using brain imaging markers to track cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Nation, Daniel a — University of Southern California
- Study coordinator: Nation, Daniel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.