Investigating brain glutamate levels and their link to suicidal behavior
Resting and Dynamic Brain Glutamate by MRS In Vivo: Relation to Suicidal Behavior
This study is looking at how levels of a brain chemical called glutamate might be linked to suicidal thoughts and behaviors in people with major depression, and it involves some brain scans to see how these levels change when faced with stress or challenges.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11033251 on NIH RePORTER |
What this research studies
This research aims to explore the relationship between brain glutamate levels and suicidal behavior by using advanced imaging techniques. Participants, including those with major depressive disorder and a history of suicidal behavior, will undergo magnetic resonance spectroscopy (MRS) to measure glutamate concentrations in the brain. The study will also assess how glutamate levels change in response to specific tasks designed to induce stress and cognitive challenges. By comparing these measurements across different groups, the research seeks to uncover critical insights into the neurobiological factors associated with suicide risk.
Who could benefit from this research
Good fit: Ideal candidates include individuals currently experiencing major depressive disorder, particularly those with a history of suicidal behavior.
Not a fit: Patients who do not have major depressive disorder or a history of suicidal behavior may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals at risk of suicide.
How similar studies have performed: While there has been some research on glutamate's role in mood disorders, this specific approach using in vivo measurements in suicidal populations is relatively novel.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Herzog, Sarah — Columbia University Health Sciences
- Study coordinator: Herzog, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.