Investigating brain function impacts of chemotherapy in children with solid tumors
Official title: Candidate mechanisms for chemotherapy-induced neurocognitive deficits in pediatric solid non-CNS tumor patients
Funded at Rutgers the State Univ of Nj Newark · NIH-10445042 · Data updated 2026-11-12
This study is looking at how chemotherapy might impact the thinking and memory skills of children aged 6-17 who have survived certain types of tumors, and it hopes to help us understand the challenges they may face compared to kids who haven't had cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | July 5, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $215,789 |
| NIH project number | 5R21CA262491-02 |
| Project ID | NIH-10445042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 6-17 years who have survived non-central nervous system solid tumors.
✕Less likely to help
Patients who have not undergone chemotherapy or those with central nervous system tumors may not benefit from this research.
What this research studies
This research focuses on understanding how chemotherapy affects brain function in children who have survived non-central nervous system solid tumors. It aims to identify the neurotoxic effects of chemotherapy on cognitive abilities such as attention, working memory, and information processing. By recruiting survivors aged 6-17 years and comparing them with typically developing peers, the study will utilize various methods, including electrophysiological and behavioral assessments, to explore differences in cognitive control and reward processing. The findings could provide insights into the long-term cognitive challenges faced by these young survivors.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive deficits in childhood cancer survivors, enhancing their quality of life.
How similar studies have gone: Previous research has shown significant cognitive deficits in childhood cancer survivors, indicating that this area of investigation is both relevant and necessary.
Where this research is happening
-
Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Baker, Travis E. — Rutgers the State Univ of Nj Newark
- Study coordinator: Baker, Travis E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.