Investigating brain fluid spaces in Alzheimer's disease using advanced imaging techniques
Official title: Exploring Perivascular spaces in Alzheimer's disease using an automated Frangi filter technique
Funded at West Virginia University · NIH-11091505 · Data updated 2026-11-12
This study is looking at tiny spaces in the brain that might help us understand Alzheimer's disease better, and it's for people with mild memory issues or Alzheimer's, as it hopes to find early signs of the disease using special imaging techniques.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project start | June 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $190,000 |
| NIH project number | 5R21AG085605-02 |
| Project ID | NIH-11091505 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those showing early signs of cognitive impairment or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients without any cognitive impairment or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of perivascular spaces (PVS) in the brain, which are linked to Alzheimer's disease and aging. By employing an automated Frangi filter technique, the study aims to detect and quantify these spaces in patients, helping to identify early biomarkers for Alzheimer's. The research will analyze PVS in a diverse group of individuals, including those with mild cognitive impairment and Alzheimer's, to uncover their significance in disease progression. This approach seeks to enhance our understanding of brain health and disease through advanced imaging methods.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better understanding of Alzheimer's disease, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using imaging techniques to identify biomarkers for Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
West Virginia University
Morgantown, United States Active
Researchers
- Principal investigator: Mehta, Rashi — West Virginia University
- Study coordinator: Mehta, Rashi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.