Investigating brain energy metabolism in schizophrenia during memory tasks
Observing brain lactate dynamics during a working memory task in first episode and chronic schizophrenia
['FUNDING_R21'] · MCLEAN HOSPITAL · NIH-11036415
This study is looking at how brain energy levels change when people with schizophrenia, whether they're just starting treatment or have been living with it for a while, work on memory tasks, to help us understand why some have trouble with memory and thinking.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MCLEAN HOSPITAL (nih funded) |
| Locations | 1 site (BELMONT, UNITED STATES) |
| Trial ID | NIH-11036415 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how brain lactate levels change during working memory tasks in individuals with schizophrenia, both in those experiencing their first episode and those with chronic conditions. By using advanced imaging techniques, the study aims to measure metabolic activity in the brain, which may reveal important insights into cognitive impairments associated with schizophrenia. The research seeks to identify differences in brain energy metabolism that could help explain why some patients struggle with memory and cognitive functions. Participants will undergo functional magnetic resonance spectroscopy (fMRS) to capture real-time changes in brain chemistry during cognitive tasks.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with schizophrenia, whether they are experiencing their first episode or have a chronic form of the illness.
Not a fit: Patients without a diagnosis of schizophrenia or those with other unrelated mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cognitive impairments in schizophrenia.
How similar studies have performed: Previous studies have shown promising results in understanding brain metabolism in schizophrenia, suggesting that this approach may yield valuable insights.
Where this research is happening
BELMONT, UNITED STATES
- MCLEAN HOSPITAL — BELMONT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, XI — MCLEAN HOSPITAL
- Study coordinator: CHEN, XI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.