Investigating brain dysfunction in survivors of sepsis related to Alzheimer's disease pathology
Enhancement of Brain Dysfunction in Sepsis Survivors by Alzheimer’s Disease Neuropathology
This study is looking at how surviving sepsis might lead to long-term brain issues, like trouble with thinking and mood, especially in older adults, and it aims to find out how certain brain changes could make these problems worse, which could help in developing new treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11002279 on NIH RePORTER |
What this research studies
This research explores how sepsis survivors may experience long-term cognitive and mood disorders due to the presence of amyloid beta (Aβ) pathology, which is common in older adults. The study aims to understand the mechanisms by which sepsis and Aβ deposition can lead to increased brain inflammation and synapse loss, potentially worsening brain function. Using a mouse model, researchers will examine the interactions between sepsis-induced immune responses and Aβ pathology to identify risk factors for brain dysfunction. The findings could provide insights into new therapeutic strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have survived sepsis and may be experiencing cognitive or mood changes.
Not a fit: Patients who have not experienced sepsis or do not have any cognitive or mood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive and mood disorders in sepsis survivors.
How similar studies have performed: Previous research has shown that similar approaches to studying the effects of amyloid pathology on brain function have yielded promising results, indicating potential for success in this area.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Singer, Benjamin Herschel — University of Michigan at Ann Arbor
- Study coordinator: Singer, Benjamin Herschel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.