Investigating brain-derived extracellular vesicles for Alzheimer's disease biomarkers
Official title: Alzheimer's disease-specific extracellular vesicles: from pathology to novel biomarker discovery
Funded at Johns Hopkins University · NIH-10739392 · Data updated 2026-11-12
This study is looking at tiny particles from the brain that could help us understand Alzheimer's disease better and find ways to detect it early, using blood tests that are easier for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,399,582 |
| NIH project number | 1RF1AG083801-01 |
| Project ID | NIH-10739392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease or those experiencing early cognitive impairments.
✕Less likely to help
Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding Alzheimer's disease by analyzing extracellular vesicles (EVs) that originate from the brain. These EVs can provide insights into the disease's progression and may serve as reliable biomarkers for early detection. By using human induced pluripotent stem cell models, the research aims to identify specific proteins in these vesicles that could indicate the presence of Alzheimer's. This approach could enhance the ability to monitor brain health through simple blood tests, potentially improving patient care.
Why it matters
Potential benefit: If successful, this research could lead to the development of new diagnostic tools for early detection of Alzheimer's disease.
How similar studies have gone: Other research has shown promise in using extracellular vesicles for biomarker discovery in various diseases, suggesting a potential for success in this novel approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Machairaki, Vasiliki — Johns Hopkins University
- Study coordinator: Machairaki, Vasiliki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.