Investigating brain connections related to dementia and walking problems in Parkinson's disease
Official title: Cerebellar cholinergic connections as a biomarker of dementia and gait impairment in Parkinson disease
Funded at Washington University · NIH-11031964 · Data updated 2026-11-12
This study is looking at how certain brain connections might affect memory and walking problems in people with Parkinson's disease, and it hopes to find clues that could help improve treatments for these challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $182,520 |
| NIH project number | 5K23NS125107-04 |
| Project ID | NIH-11031964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are experiencing cognitive decline or gait impairment.
✕Less likely to help
Patients with Parkinson's disease who do not exhibit any cognitive or gait impairments may not benefit from this research.
What this research studies
This research explores the relationship between cholinergic connections in the brain and the development of dementia and gait impairment in patients with Parkinson's disease. By using advanced imaging techniques, the study aims to understand how changes in specific brain regions, particularly the cerebellum, may contribute to cognitive decline and difficulties in walking. Patients will be monitored over time to assess how these brain changes correlate with their symptoms. The goal is to identify potential biomarkers that could lead to better treatment strategies for these debilitating conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients suffering from dementia and gait issues associated with Parkinson's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of brain connectivity in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Maiti, Baijayanta — Washington University
- Study coordinator: Maiti, Baijayanta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.