Investigating brain connections in infants with periventricular leukomalacia
Thalamo-cortical circuitry in PVL
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10913381
This study is looking at how brain injuries in premature babies, especially a condition called periventricular leukomalacia (PVL), impact their thalamus and its connections to the brain's outer layer, and it aims to see how these changes might relate to any vision problems they might have.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10913381 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how brain injuries, specifically periventricular leukomalacia (PVL), affect the thalamus and its connections to the cerebral cortex in premature infants. By using advanced imaging techniques like diffusion MRI, the study aims to explore how changes in brain structure and connectivity relate to visual processing difficulties in these infants. Participants will undergo a series of imaging tests and visual function assessments to identify potential links between brain abnormalities and visual impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants diagnosed with periventricular leukomalacia who are experiencing visual processing difficulties.
Not a fit: Patients who are not premature or do not have a diagnosis of periventricular leukomalacia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for visual impairments in infants affected by PVL.
How similar studies have performed: Previous research has shown promising results in understanding brain connectivity and visual processing in similar populations, indicating that this approach may yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAUER, CORINNA M — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: BAUER, CORINNA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury