Investigating brain circuits related to neuropsychiatric symptoms in Alzheimer's disease
Official title: Assess Neural Circuits and Subtypes Underlying Dimensions of Neuropsychiatric Symptoms in Alzheimer's Disease
Funded at Lehigh University · NIH-10931617 · Data updated 2026-11-12
This study is looking at how brain activity is linked to the symptoms people with Alzheimer's disease and mild cognitive impairment experience, with the hope of finding better ways to diagnose and treat these conditions early on.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lehigh University NIH-funded |
| Lab location | 1 site (Bethlehem, United States) |
| Project start | September 20, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $226,566 |
| NIH project number | 5R21AG080425-02 |
| Project ID | NIH-10931617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with mild cognitive impairment or Alzheimer's disease who are experiencing neuropsychiatric symptoms.
✕Less likely to help
Patients with neuropsychiatric symptoms not related to Alzheimer's disease or those in advanced stages of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the neural circuits and subtypes that contribute to neuropsychiatric symptoms in individuals with Alzheimer's disease and mild cognitive impairment. By examining how these symptoms manifest and their relationship to brain function, the study aims to identify specific patterns of neural activity that correlate with different dimensions of these symptoms. The approach involves advanced neurobiological assessments to uncover the underlying mechanisms, which could lead to better diagnostic and therapeutic strategies for patients. Ultimately, the goal is to enhance early detection and intervention to slow the progression of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of neuropsychiatric symptoms in Alzheimer's patients, potentially slowing disease progression.
How similar studies have gone: Previous research has shown promising results in understanding neuropsychiatric symptoms in Alzheimer's disease through similar neurobiological approaches, indicating potential for success in this study.
Where this research is happening
-
Lehigh University
Bethlehem, United States Active
Researchers
- Principal investigator: Zhang, Yu — Lehigh University
- Study coordinator: Zhang, Yu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.