Investigating brain circuits involved in spatial memory and navigation.
Retrosplenial Cortex Circuit Interactions Supporting Spatial Cognition and Memory
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA SANTA BARBARA · NIH-10928128
This study is looking at how certain parts of the brain help us remember where we are and how to get around, especially for people with Alzheimer's, to better understand why they might get lost or forget things.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA BARBARA (nih funded) |
| Locations | 1 site (SANTA BARBARA, UNITED STATES) |
| Trial ID | NIH-10928128 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific brain circuits in the retrosplenial cortex (RSC) contribute to spatial cognition and memory. By examining how the RSC processes spatial information, the study aims to uncover the mechanisms behind spatial disorientation and memory deficits, particularly in the context of Alzheimer's disease. The research employs advanced techniques such as high-density extracellular recordings and in vivo neuroimaging to observe brain activity and its relation to navigation and memory. This could lead to insights into how these cognitive functions are affected in patients with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive decline or memory issues, particularly those diagnosed with Alzheimer's disease.
Not a fit: Patients with cognitive impairments not related to spatial memory or those without Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for memory and navigation issues in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding brain circuits related to cognition, suggesting that this approach could yield valuable insights.
Where this research is happening
SANTA BARBARA, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA BARBARA — SANTA BARBARA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALEXANDER, ANDREW S. — UNIVERSITY OF CALIFORNIA SANTA BARBARA
- Study coordinator: ALEXANDER, ANDREW S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease pathology