Investigating brain circuits involved in mental health treatment
Preclinical Assays of Hippocampal-Prefrontal Cortical Circuit Engagement for Application in Therapeutic Development
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10868627
This study is looking at how certain brain connections work and how they relate to mental health issues, with the hope of finding better treatments for patients by learning more about how our brains handle thinking tasks.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10868627 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific brain circuits, particularly the hippocampal-prefrontal cortical circuit, function in relation to mental health disorders. By using preclinical assays, the study aims to identify physiological and behavioral measures that indicate how these circuits engage during cognitive tasks. The goal is to improve the therapeutic development pipeline for psychiatric diseases by establishing better models for drug efficacy and target discovery. Patients may benefit from advancements in treatment options that are based on a deeper understanding of brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with anxiety, bipolar disorder, schizophrenia, or autism.
Not a fit: Patients with conditions unrelated to the hippocampal-prefrontal cortical circuit may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for various mental health disorders.
How similar studies have performed: Other research has shown promise in understanding brain circuits for therapeutic development, suggesting that this approach could yield significant insights.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAURER, ANDREW PORTER — UNIVERSITY OF FLORIDA
- Study coordinator: MAURER, ANDREW PORTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder