Investigating brain circuit dysfunction in schizophrenia using advanced computational methods
An integrative computational interrogation of circuit dysfunction inschizophrenia via neural timescales
This study is looking at how schizophrenia affects the brain by comparing data from people with the condition and those without it, to better understand what happens in the brain and how it relates to symptoms, which could lead to better ways to diagnose and treat the disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10866558 on NIH RePORTER |
What this research studies
This research aims to understand the complex mechanisms behind schizophrenia by analyzing large datasets that include both healthy individuals and patients. It employs a hybrid approach that combines data-driven methods with theoretical frameworks to explore genetic, developmental, and cognitive aspects of the disorder. By measuring intrinsic neural timescales from brain imaging data, the study seeks to identify specific alterations in brain function associated with schizophrenia and how these changes relate to symptoms. The findings could help clarify the underlying causes of schizophrenia and improve diagnostic and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with schizophrenia as well as healthy participants for comparative analysis.
Not a fit: Patients with conditions unrelated to schizophrenia or those who do not meet the study's inclusion criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals with schizophrenia.
How similar studies have performed: Previous research has shown promise in using computational approaches to understand brain disorders, indicating potential for success in this novel investigation.
Where this research is happening
New York, United States
- New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC — New York, United States (Active)
Researchers
- Principal investigator: Horga, Guillermo — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Horga, Guillermo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.