Investigating brain circuit dysfunction in Fragile X Syndrome using mouse models
FMRP regulation of local and long-range neocortical circuits in the mouse: Links with EEG phenotypes
['FUNDING_OTHER'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11179539
This study is looking at how certain brain circuits work in people with Fragile X Syndrome by using mice that have similar traits, hoping to find ways to fix the brain issues that come with the condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11179539 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific brain circuits are affected in Fragile X Syndrome (FXS) by studying mouse models that mimic the condition. Researchers have identified abnormal brain activity patterns, known as EEG phenotypes, that are present in both humans with FXS and these mouse models. By examining the hyperexcitability of local brain circuits and the reduced connections between different brain regions, the study aims to uncover the underlying mechanisms of these dysfunctions. The findings could lead to potential therapeutic strategies to correct these circuit defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome or those with related genetic conditions.
Not a fit: Patients without Fragile X Syndrome or similar genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain function and clinical outcomes for patients with Fragile X Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding brain circuit dysfunctions in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUBER, KIMBERLY M. — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: HUBER, KIMBERLY M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.