Investigating brain circuit dysfunction in Fragile X Syndrome using mouse models
FMRP regulation of local and long-range neocortical circuits in the mouse: Links with EEG phenotypes
['FUNDING_OTHER'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10907671
This study is looking at how the missing FMR1 gene affects brain connections in mice, which could help us understand similar problems in people with Fragile X Syndrome, and the goal is to find out what goes wrong in the brain to help develop better treatments for those with the condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10907671 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the loss of the FMR1 gene affects brain circuits in mice, which may mirror similar issues in humans with Fragile X Syndrome (FXS). By studying the electrical activity in the brains of Fmr1 knockout mice, researchers aim to identify specific circuit defects that lead to abnormal EEG patterns. The study involves examining local and long-range connections in the brain to determine how these dysfunctions contribute to the symptoms of FXS. The findings could provide insights into potential therapeutic approaches for individuals with FXS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome or those who exhibit related symptoms.
Not a fit: Patients without a diagnosis of Fragile X Syndrome or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain function and quality of life for patients with Fragile X Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding brain circuit dysfunctions in similar genetic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUBER, KIMBERLY M. — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: HUBER, KIMBERLY M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.