Investigating brain circuit dysfunction in a model of childhood epilepsy
Neocortical and Hippocampal Circuit Dysfunction in the KCNT1 Model of Epilepsy
['FUNDING_R21'] · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · NIH-11056387
This study is looking at how changes in a specific gene related to epilepsy might affect brain activity during seizures and learning, using mice to help find better ways to manage epilepsy and improve thinking skills.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VERMONT & ST AGRIC COLLEGE (nih funded) |
| Locations | 1 site (BURLINGTON, UNITED STATES) |
| Trial ID | NIH-11056387 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how genetic variants in the KCNT1 gene affect brain circuits involved in epilepsy and cognitive function. Using a mouse model, the study will explore the activity of specific types of brain cells during seizures and learning tasks. By employing advanced techniques like high-density electrophysiology and optogenetics, researchers aim to uncover the mechanisms behind altered brain activity in epilepsy. This could lead to insights into how to better manage or treat epilepsy and related cognitive deficits.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with epilepsy linked to KCNT1 gene variants or similar developmental seizure disorders.
Not a fit: Patients without KCNT1 gene variants or those with other unrelated forms of epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for childhood epilepsy and associated cognitive impairments.
How similar studies have performed: Previous research has shown promising results in understanding epilepsy mechanisms through similar electrophysiological approaches, indicating potential for success in this study.
Where this research is happening
BURLINGTON, UNITED STATES
- UNIVERSITY OF VERMONT & ST AGRIC COLLEGE — BURLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARRY, JEREMY MICHAEL — UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- Study coordinator: BARRY, JEREMY MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.