Investigating brain circuit changes in aging and Alzheimer's disease
Cell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer's disease
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11092733
This study is looking at how aging and Alzheimer's disease affect important brain areas that help with memory, using special mouse models to learn more about the changes in brain connections, which could help find new treatments for people with Alzheimer's.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11092733 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how aging and Alzheimer's disease (AD) affect specific brain circuits, particularly in the hippocampus, which is crucial for memory and cognition. By using advanced mouse models that mimic human AD features, the team will map the connections and changes in these circuits at a cellular level. The study employs cutting-edge techniques such as single-cell transcriptomics and neural circuit mapping to gather detailed information about how these changes contribute to cognitive decline. Patients may benefit from insights gained that could lead to new therapeutic strategies for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease.
Not a fit: Patients with early-stage cognitive impairment or those without any signs of cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better target the underlying causes of cognitive decline in Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in mapping neural circuits in relation to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, XIANGMIN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: XU, XIANGMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder, age related human disease