Investigating brain changes related to memory in Alzheimer's disease
Mechanisms of pathology and neuronal hyperactivity in a memory circuit in Alzheimer's disease
['FUNDING_R01'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-10885049
This study is looking at how certain parts of the brain, especially the mamillary body, are impacted by amyloid buildup in Alzheimer's disease, using mice to learn more about the types of brain cells involved and how they affect memory, with hopes of finding new treatments for people with Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10885049 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific brain regions, particularly the mamillary body, are affected by amyloid deposits in Alzheimer's disease. By studying mouse models, researchers aim to identify distinct types of neurons in this area and how their activity relates to memory performance. The project employs advanced techniques like single-cell RNA sequencing and microscopy to explore the connections between amyloid accumulation and neuronal hyperactivity. The ultimate goal is to uncover mechanisms that could lead to new therapeutic strategies for Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those with genetic risk factors such as the APOE ε4 allele.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments that improve memory function in Alzheimer's disease patients.
How similar studies have performed: Previous studies have shown promising results in understanding the role of amyloid in Alzheimer's, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOYDEN, EDWARD S. — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: BOYDEN, EDWARD S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease model