Investigating brain changes related to Alzheimer's disease and related dementias.
Adult Changes in Thought (ACT) Research Program Core D: Neuropathology Core
This study is looking at brain tissue from people with Alzheimer's and similar conditions to better understand how these diseases affect the brain, using new technology to help find ways to improve treatment and care for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project ID | NIH-11124773 on NIH RePORTER |
What this research studies
This research focuses on understanding the neuropathology of Alzheimer's disease and related dementias by utilizing advanced techniques to analyze brain tissue. The study employs innovative methods such as 3D virtual brain reconstructions and deep learning image analysis to capture and quantify changes in brain structure and pathology. By examining post-mortem brain samples, the research aims to uncover the underlying mechanisms of these diseases and identify factors that contribute to their variability. This work is crucial for developing targeted interventions and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those who may be willing to contribute their brain tissue for study after passing.
Not a fit: Patients who are not diagnosed with Alzheimer's disease or related dementias may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown success in utilizing advanced imaging and molecular profiling techniques to study Alzheimer's disease, indicating that this approach is promising.
Where this research is happening
Oakland, UNITED STATES
- Kaiser Foundation Research Institute — Oakland, United States (Active)
Researchers
- Principal investigator: Keene, Christopher Dirk — Kaiser Foundation Research Institute
- Study coordinator: Keene, Christopher Dirk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.